Hagit Eldar-Finkelman

/Hagit Eldar-Finkelman
Hagit Eldar-Finkelman 2017-02-27T19:15:41+00:00

Prof. Hagit Eldar-Finkelman, Ph.D.

Professor at the Department of Human Molecular Genetics & Biochemistry

EDUCATION

  • BSc- Chemistry The Hebrew University of Jerusalem, 1984
  • MSc- The Weizmann Institute of Science, 1987
  • PhD -The Weizmann Institute of Science, 1993

Postgraduate Training

  • Postdoctoral Fellowship, University of Washington, Seattle
    (c/o Nobel Prize Laurent  E.G. Krebs), 1993 -1998

ACADEMIC APPOINTMENTS AND ACTIVITIES

Academic Appointments

  • Professor, Department of Human Molecular Genetics & Biochemistry,  Sackler School of Medicine, Tel Aviv  University, Israel, 2012-
  • Associate Professor, Department of Human Molecular Genetics & Biochemistry,  Sackler School of Medicine, Tel Aviv  University, Israel, 2006-2012
  • Senior lecturer, Department of Human Molecular Genetics & Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel, 1999-2006
  • Assistant professor, Department of Medicine, Harvard Medical School, Boston, USA, 1998-2001

Academic Services/activities

  • Student academic consultant, Sackler School of Medicine, 2000-2004
  • Faculty committee of Msc students, Member, 2004-2010
  • University committee of Msc academic studies, Member, 2006-2010
  • University committee for Animal care and ethics, Chair, 2007-2011
  • Inter-University Forum for Medical Sciences in Israel, Member, 2005-2010
  • Vice Dean for Animal care and ethics, 2010-2013
  • National committee for Animal care and ethics, Member, 2010-2013
  • ‘Charadim to Medicine’-a new program to advance medical studies among the Jewish orthodox community, Coordinator, 2012-2013
  • The Israel Society for Neuroscience, Member, 2010-2014
  • International Advisory Board of IPK (inhibitors for protein kinases), Member, 2009- 2014
  • Faculty committee for PhD students, Chair, 2011-
  • University ‘small’ Senate, Member, 2013-

AWARDS

  • British Council Award,1987
  • American Heart Association Award 1994
  • Joslin Diabetes Center Fellowship in Memory of Dr. Priscilla White 50th Anniversary Program for Scholars in Medicine, Harvard Medical School 1999
  • New Investigator Award, Medical Foundation, Boston, 1999
  • The Annual Award of The Hendrik and Irene Gutwirh Research Prize In Diabetes Mellitus, 2000
  • Israeli Diabetes Association Award for distinguished  scientist,  2003
  • Lindner Prize of the Israel Endocrine Society, 2008

PUBLICATIONS 1986-1999

1. Saper, M.A., Eldar, H., Nickole, J., Appela, E. Sussman, J.L. 1986, Crystalization of a DNA tridecamer. J. Mol. Biol.; 188:111-3.

2. Eldar, H., Degani, H. 1989, 31P NMR studies of the thermodynamics and kinetics of the creatine kinase reaction. J. Magn. Reson. Med.; 11:12126.

3. Neeman, M., Eldar, H., Rushkin, E., Degani, H.1990, Chemotherapy-induced changes in the energetics of human breast cancer cells, 31P and 13C NMR studies. Biochem. et. Biophys. Acta.; 1052:55-63.

4. Seymour, A.M., Eldar, H., Radda, G.K. 1990, Hyperthyrodism results in increased glycolytic capacity  in the rat heart. 31P NMR studies. Biochem. et Biophys. Acta.;1055:107-16.

5. Eldar, H., Zisman, Y., Ullrich, A., Livneh, E. 1990, Overexpression of protein kinase C-a subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptors for epidermal growth factor. J. Biol. Chem. 265:13290-296.

6. Eldar-Finkelman, H., Zisman, Y., Ullrich, A., and Livneh, E. 1990. Overexpression of protein kinase C-a in Swiss/3T3 cells reduces the  number of both high and low affinity of the epidermal growth factor  Signal Transduction, Vol. 51, p. 271-81: Springer-Verlag press.

7. Raber, J., Eldar, H., Lehrer, R., Chabath, J., Livneh, E. 1991, Regulation of the interferon-induced 100kda 2′-5′ A synthetase by A23187 and Protein Kinase C. Eur. Cytokine Net.; 2: 281-90.

8. Greif, H., Ben-Chaim, J., Shimon, T., Bechor, E., Eldar, H., Livneh, E. 1992, The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. Mol. Cell. Biol.; 123:1304-11.

9. Eldar, H,. Ben-Chaim, J., Livne, E. 1992, Deletions in the regulatory or kinase domains of protein kinase C-a causes association with the cell nucleus. Exp. Cell. Res. 202: 259-66.

10. Eldar, H., Livneh, E. 1992, Phosphorylation of p90 and p52 accompanies the response to phorbol esters in Swiss/3T3 cells overexpressing protein kinase C-a. Mol. Biol. Cell. 3:1049-56.

11. Slack, B.E., Nitsch, R.M., Livneh, E. Kunz, G.M., Breu, J., Eldar, H., Wurtman, R.J. 1992, Regulation by phorbol esters of amyloid precursor protein release from Swiss/3T3 fibroblasts overexpressing protein kinase C-a. J. Biol. Chem.; 268:21097-101.

12. Liscovitch, M., Ben-Av, P., Danin, M., Faiman, G., Eldar, H., Livneh, E. 1993, Phospholipase D-mediated hydrolysis of phosphatidylcholine: Role in cell signaling. J. Lipid Mediators  8:177-82.

13. Eldar, H., Ben-Av, P., Schmidt, U.S., Livneh, E., Liscovitch, M. 1993, Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-a. Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro J. Biol. Chem. 268:12560-64.

14.  Slack, B.E., Nitsch, R.M., Livneh, E., Kunz, G.M. Jr, Eldar, H., Wurtman, R.J. 1993 Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Ann N Y Acad Sci. 695:128-31.

15. Fitzer-Attas, C., Eldar, H., Eisenbach, L., Livneh, E. 1994, Expression of PDGF-a but not PDGF-b receptor is regulated in protein kinase C-a overexpressing Swiss/3T3 fibroblasts. FEBS-Lett. 342:165-70.

16. Seger, R., Seger, D., Reszka, A.A., Munar, E.S., Eldar-Finkelman, H., Dobrowolska, G., Jensen, A.M., Campbell, J.S., Fischer E.H., Krebs, E.G. 1994, Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J. Biol. Chem. 269:25699-709.

17. Slack, B.E., Breu, J., Livneh E., Eldar, H., Wurtman, R.J. 1995, Phorbol esters stimulate choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C a. Biochem. .J. 305: 621-6.

18. Eldar-Finkelman H., Seger, R., Vandenheede, J .R., Krebs, E.G. 1995, inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J. Biol. Chem. 270:987-90.

19. Eldar-Finkelman, H., Agrast G.M., Foord O., Fischer E.H. Krebs E.G. 1996, Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity. Proc. Natl. Acad. Sci. USA 93:10228-33.

20. Eldar-Finkelman H., Krebs E.G. 1997, Phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 impairs insulin action. Proc. Natl. Acad. Sci. USA 94:9660-64.

21. Torres M., Eldar-Finkelman, H. Krebs, E.G. Moon, R.T. 1999, Regulation of S6 ribosomal protein kinase p90 RSK, glycogen synthase kinase-3 and b-catenin in Early Xenopus Development. Mol. Cell Biol. 19:1427-37.

22. Eldar-Finkelman H. Schreyer, S.A., M.M. Shinohara, M.M., Leboeuf, R.C., Krebs, E.G.1999, Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice Diabetes 48:1662-1666.

23.  Zhao, A.Z., Shinohara, M.M., Huang, D., Shimizu, M., Eldar-Finkelman, H. Krebs, E.G., Beavo, J.V., Bornfeldt, K.E. 2000, Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes.  J. Biol. Chem. 275:11348-54.

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