Prof. Hagit Eldar-Finkelman, Ph.D.

Professor At The Department Of
Human Molecular Genetics & Biochemistry

Education

BSc- Chemistry The Hebrew University of Jerusalem, 1984

MSc- The Weizmann Institute of Science, 1987

PhD -The Weizmann Institute of Science, 1993

Academic Appointments

Professor, Department of Human Molecular Genetics & Biochemistry,  Sackler School of Medicine, Tel Aviv  University, Israel, 2012-

 

Associate Professor, Department of Human Molecular Genetics & Biochemistry,  Sackler School of Medicine, Tel Aviv  University, Israel, 2006-2012

 

Senior lecturer, Department of Human Molecular Genetics & Biochemistry, Sackler School of Medicine, Tel Aviv University, Israel, 1999-2006

 

Assistant professor, Department of Medicine, Harvard Medical School, Boston, USA, 1998

Academic Services/activities

Student academic consultant, Sackler School of Medicine, 2000-2004
 
Faculty committee of Msc students, Member, 2004-2010
 
University committee of Msc academic studies, Member, 2006-2010
 
University committee for Animal care and ethics, Chair, 2007-2011
 
Inter-University Forum for Medical Sciences in Israel, Member, 2005-2010
 
Vice Dean for Animal care and ethics, 2010-2013
 
National committee for Animal care and ethics, Member, 2010-2013
 
‘Charadim to Medicine’-a new program to advance medical studies among the Jewish orthodox community, Coordinator, 2012-2013
 
The Israel Society for Neuroscience, Member, 2010-2014
 
International Advisory Board of IPK (inhibitors for protein kinases), Member, 2009- 2014
 
Faculty committee for PhD students, Chair, 2011-
University ‘small’ Senate, Member, 2013-

Publication List - Years 1986-2000

1. Saper, M.A., Eldar, H., Nickole, J., Appela, E. Sussman, J.L. 1986, Crystalization of a DNA tridecamer. J. Mol. Biol.; 188:111-3.

2. Eldar, H., Degani, H. 1989, 31P NMR studies of the thermodynamics and kinetics of the creatine kinase reaction. J. Magn. Reson. Med.; 11:12126.

3. Neeman, M., Eldar, H., Rushkin, E., Degani, H.1990, Chemotherapy-induced changes in the energetics of human breast cancer cells, 31P and 13C NMR studies. Biochem. et. Biophys. Acta.; 1052:55-63.

4. Seymour, A.M., Eldar, H., Radda, G.K. 1990, Hyperthyrodism results in increased glycolytic capacity  in the rat heart. 31P NMR studies. Biochem. et Biophys. Acta.;1055:107-16.

5. Eldar, H., Zisman, Y., Ullrich, A., Livneh, E. 1990, Overexpression of protein kinase C-a subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptors for epidermal growth factor. J. Biol. Chem. 265:13290-296.

6. Eldar-Finkelman, H., Zisman, Y., Ullrich, A., and Livneh, E. 1990. Overexpression of protein kinase C-a in Swiss/3T3 cells reduces the  number of both high and low affinity of the epidermal growth factor  Signal Transduction, Vol. 51, p. 271-81: Springer-Verlag press.

7. Raber, J., Eldar, H., Lehrer, R., Chabath, J., Livneh, E. 1991, Regulation of the interferon-induced 100kda 2′-5′ A synthetase by A23187 and Protein Kinase C. Eur. Cytokine Net.; 2: 281-90.

8. Greif, H., Ben-Chaim, J., Shimon, T., Bechor, E., Eldar, H., Livneh, E. 1992, The protein kinase C-related PKC-L(eta) gene product is localized in the cell nucleus. Mol. Cell. Biol.; 123:1304-11.

9. Eldar, H,. Ben-Chaim, J., Livne, E. 1992, Deletions in the regulatory or kinase domains of protein kinase C-a causes association with the cell nucleus. Exp. Cell. Res. 202: 259-66.

10. Eldar, H., Livneh, E. 1992, Phosphorylation of p90 and p52 accompanies the response to phorbol esters in Swiss/3T3 cells overexpressing protein kinase C-a. Mol. Biol. Cell. 3:1049-56.

11. Slack, B.E., Nitsch, R.M., Livneh, E. Kunz, G.M., Breu, J., Eldar, H., Wurtman, R.J. 1992, Regulation by phorbol esters of amyloid precursor protein release from Swiss/3T3 fibroblasts overexpressing protein kinase C-a. J. Biol. Chem.; 268:21097-101.

12. Liscovitch, M., Ben-Av, P., Danin, M., Faiman, G., Eldar, H., Livneh, E. 1993, Phospholipase D-mediated hydrolysis of phosphatidylcholine: Role in cell signaling. JLipid Mediators  8:177-82.

13. Eldar, H., Ben-Av, P., Schmidt, U.S., Livneh, E., Liscovitch, M. 1993, Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-a. Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro J. Biol. Chem. 268:12560-64.

14.  Slack, B.E., Nitsch, R.M., Livneh, E., Kunz, G.M. Jr, Eldar, H., Wurtman, R.J. 1993 Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts. Ann N Y Acad Sci. 695:128-31.

15. Fitzer-Attas, C., Eldar, H., Eisenbach, L., Livneh, E. 1994, Expression of PDGF-a but not PDGF-b receptor is regulated in protein kinase C-a overexpressing Swiss/3T3 fibroblasts. FEBS-Lett. 342:165-70.

16. Seger, R., Seger, D., Reszka, A.A., Munar, E.S., Eldar-Finkelman, H., Dobrowolska, G., Jensen, A.M., Campbell, J.S., Fischer E.H., Krebs, E.G. 1994, Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J. Biol. Chem. 269:25699-709.

17. Slack, B.E., Breu, J., Livneh E., Eldar, H., Wurtman, R.J. 1995, Phorbol esters stimulate choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C a. Biochem. .J. 305: 621-6.

18. Eldar-Finkelman H., Seger, R., Vandenheede, J .R., Krebs, E.G. 1995, inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J. Biol. Chem. 270:987-90.

19. Eldar-Finkelman, H., Agrast G.M., Foord O., Fischer E.H. Krebs E.G. 1996, Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity. Proc. Natl. Acad. Sci. USA 93:10228-33.

20. Eldar-Finkelman H., Krebs E.G. 1997, Phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 impairs insulin action. Proc. Natl. Acad. Sci. USA 94:9660-64.

21. Torres M., Eldar-Finkelman, H. Krebs, E.G. Moon, R.T. 1999, Regulation of S6 ribosomal protein kinase p90 RSK, glycogen synthase kinase-3 and b-catenin in Early Xenopus Development. Mol. Cell Biol. 19:1427-37.

22. Eldar-Finkelman H. Schreyer, S.A., M.M. Shinohara, M.M., Leboeuf, R.C., Krebs, E.G.1999, Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice Diabetes 48:1662-1666.

23.  Zhao, A.Z., Shinohara, M.M., Huang, D., Shimizu, M., Eldar-Finkelman, H. Krebs, E.G., Beavo, J.V., Bornfeldt, K.E. 2000, Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes.  J. Biol. Chem. 275:11348-54.