The research in our laboratory is focused on the molecular pathways regulated by the serine/threonine kinase, glycogen synthase kinase-3 (GSK-3), and their implications in pathological disorders. In recent years GSK-3 is emerged as a drug discovery target involved in diabetes, neurodegenerative and affective disorders, including Alzheimer’s disease (AD), Parkinson’s disease, and bipolar disorder. Our aim is to identify mechanisms linking hyperactivity of GSK-3 with these pathologies.
Our laboratory employ multidisciplinary research platforms to address frontier challenges in disease mechanisms and potential solutions. We use molecular and cellular biology, in vitro assays, animal models, and computational tools.